The Advent of Recombinant Pertussis Vaccines
نویسندگان
چکیده
منابع مشابه
Pertussis Vaccines
s of references provided in the position paper and GRADE tables Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet 2014 Oct 25; 384(9953):1521-1528. BACKGROUND: In October, 2012, a pertussis vaccination programme for pregnant women was introduced in response to an outbreak acro...
متن کاملBordetella pertussis and pertussis vaccines.
Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the a...
متن کاملBordetella pertussis polymorphism and pertussis vaccines.
The topic of the article by Bottero et al. (1) is an important one, a bacterial vaccine for a preventable disease, pertussis. Many articles have been published on the subject in the last 10 years (for a review, see reference 6). In their study, Bottero et al. neither followed the recommendations of consensus meetings nor used published nomenclature. Furthermore, they compared vaccines that cann...
متن کاملReflections on the efficacy of pertussis vaccines.
The literature on the protection imparted by conventional whole-cell pertussis vaccines was reviewed, and the extent to which the great variation in estimates of vaccine efficacy is attributable to methodologic problems in study design and analysis or to biologic features of the natural history of pertussis was explored. The protection against disease imparted by pertussis vaccines may be great...
متن کاملEstimating the effectiveness of acellular pertussis vaccines.
TO THE EDITOR—In the 15 June 2012 issue of Clinical Infectious Diseases, Witt et al reported that vaccine effectiveness (VE) of acellular pertussis vaccines was 41% for children aged 2–7 years, 24% for 8to 12-year-olds, and 79% for 13to 18-year-olds [1]. The authors conclude that their data “confirms markedly lower than expected protection afforded by the pre-school series of acellular pertussi...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1990
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt1190-1002